Effect of calcium dobesilate on the blood-retinal barrier in early diabetic retinopathy

International Ophthalmology 14: 81-88, 1990

 

Effect of calcium dobesilate on the blood-retinal barrier in early diabetic retinopathy

 

E.B. Leite, M.C. Mota, J.R. Faria de Abreu & J.G. Cunha-Vaz

 

Department of Ophthalmology and Ophthalmology Research Center, Universitoyf Coimbra, Coimbra, Portugal

 

Summary

The effect of calcium dobesilate on the alteration of the blood-retinal barrier was studied in 41 adult-onset, non-insulin dependent diabetic patienwtsi th minimal or nor etinopathy, randomly assigned to receive either oral calcium dobesilate (1000 mgtw ice daily) or a placebo for 12 months. The posterior vitreous value and the penetration ratio, determined by vitreous fluorophotometry, reflected stabilisation of blood-retinal barrier permeability in the calcium dobesilate patients and deterioration of blood retinal barrier in those given placebo. During the relatively short period of the study, one year, no significant change in microaneurysm and capillary closure gradings was observed. No side effects were associated with calcium dobesilate.

 

(Reference link : https://link.springer.com/article/10.1007/BF00154206)